Title : Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen.

Pub. Date : 2021 Jun 15

PMID : 34159337






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In human lung organoids, lapatinib protects from SARS-CoV-2-induced activation of pathways implicated in non-infectious acute lung injury and fibrosis downstream of ErbBs (p38-MAPK, MEK/ERK, and AKT/mTOR), pro-inflammatory cytokine production, and epithelial barrier injury. Lapatinib AKT serine/threonine kinase 1 Homo sapiens