Pub. Date : 2021 Jun 21
PMID : 34155225
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab. | Disulfides | FA complementation group B | Homo sapiens |
| 2 | To identify sites where intermolecular disulfide bond can be introduced into the Fab"s constant domain of the therapeutic IgG, Fab mutants were predicted using the MOE software, a molecular simulator, and expressed in Pichia pastoris. | Disulfides | FA complementation group B | Homo sapiens |
| 3 | To identify sites where intermolecular disulfide bond can be introduced into the Fab"s constant domain of the therapeutic IgG, Fab mutants were predicted using the MOE software, a molecular simulator, and expressed in Pichia pastoris. | Disulfides | FA complementation group B | Homo sapiens |
| 4 | All these mutants showed increased thermal stability compared to that of Fab without intermolecular disulfide bond. | Disulfides | FA complementation group B | Homo sapiens |
| 5 | Thus, our comprehensive analysis reveals that the introduction of intermolecular disulfide bond in the Fab"s constant domain is possible at various locations. | Disulfides | FA complementation group B | Homo sapiens |