Pub. Date : 2021 Aug
PMID : 34149884
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-125b-5p inhibits cell proliferation by targeting ASCT2 and regulating the PI3K/AKT/mTOR pathway in an LPS-induced intestinal mucosa cell injury model. | mir-125b-5p | solute carrier family 1 member 5 | Homo sapiens |
| 2 | The interaction between miR-125b-5p and ASCT2 was analyzed using a dual luciferase reporter assay. | mir-125b-5p | solute carrier family 1 member 5 | Homo sapiens |
| 3 | Furthermore, miR-125b-5p mimic transfection resulted in a decrease of ASCT2 mRNA and protein expression, whereas the inhibitor increased ASCT2 mRNA and protein expression. | mir-125b-5p | solute carrier family 1 member 5 | Homo sapiens |
| 4 | Furthermore, miR-125b-5p mimic transfection resulted in a decrease of ASCT2 mRNA and protein expression, whereas the inhibitor increased ASCT2 mRNA and protein expression. | mir-125b-5p | solute carrier family 1 member 5 | Homo sapiens |
| 5 | Dual luciferase reporter assays suggested that ASCT2 was a direct target of miR-125b-5p, and its restoration weakened the effect of miR-125b-5p on LPS-induced intestinal mucosa cell injury. | mir-125b-5p | solute carrier family 1 member 5 | Homo sapiens |
| 6 | Overall, the present study indicated that miR-125b-5p accelerated LPS-induced intestinal mucosa cell injury by targeting ASCT2 and upregulating the PI3K/AKT/mTOR pathway. | mir-125b-5p | solute carrier family 1 member 5 | Homo sapiens |