Title : Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis.

Pub. Date : 2021

PMID : 34149413






1 Functional Relationships(s)
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1 In addition, GRP78 overexpression promoted autophagy-inducing chemoresistance in breast cancer cells by stabilizing beta-catenin, while ADQ treatment downregulated GRP78, activated the Akt/GSK3beta-mediated proteasome degradation of beta-catenin via ubiquitination activation, and consequently attenuated the chemoresistance-promoted effect of GRP78. ADP-glucose thymoma viral proto-oncogene 1 Mus musculus