Title : Fragment-based screening and hit-based substructure search: Rapid discovery of 8-hydroxyquinoline-7-carboxylic acid as a low-cytotoxic, nanomolar metallo β-lactamase inhibitor.

Pub. Date : 2021 Oct

PMID : 34148302






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A hit-based substructure search provided an early structure activity relationship of 8-hydroxyquinolines and identified 8-hydroxyquinoline-7-carboxylic acid as a low cytotoxic beta-lactamase inhibitor that can restore beta-lactam activity against VIM-2 expressing E. coli. 8-hydroxyquinoline-7-carboxylic acid vimentin 2, pseudogene Homo sapiens