Title : The anti-inflammatory effect of ε-viniferin by specifically targeting formyl peptide receptor 1 on human neutrophils.

Pub. Date : 2021 Aug 25

PMID : 34144024






3 Functional Relationships(s)
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1 Briefly, epsilon-viniferin specifically inhibited fMLP (0.1 muM: formyl peptide receptor 1 agonist or 1 muM: formyl peptide receptor 1, 2 agonist)-induced superoxide anion production in a concentration-dependent manner (IC50=2.30+-0.96 or 9.80+-0.21 muM, respectively) without affecting this induced by formyl peptide receptor 2 agonist (WKYMVM). Superoxides formyl peptide receptor 1 Homo sapiens
2 Briefly, epsilon-viniferin specifically inhibited fMLP (0.1 muM: formyl peptide receptor 1 agonist or 1 muM: formyl peptide receptor 1, 2 agonist)-induced superoxide anion production in a concentration-dependent manner (IC50=2.30+-0.96 or 9.80+-0.21 muM, respectively) without affecting this induced by formyl peptide receptor 2 agonist (WKYMVM). Superoxides formyl peptide receptor 1 Homo sapiens
3 ATPgammaS induced superoxide anion production through formyl peptide receptor 1 in fMLP desensitized neutrophils and this effect was inhibited by epsilon-viniferin. Superoxides formyl peptide receptor 1 Homo sapiens