Pub. Date : 2021 Jun 17
PMID : 34140545
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-beta-treated epithelial cancer cells. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Moreover, treatment of cells with atorvastatin prior to TGF-beta treatment enhanced this effect, which was further potentiated by the simultaneous reduction in the expression of the statin target enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | Moreover, treatment of cells with atorvastatin prior to TGF-beta treatment enhanced this effect, which was further potentiated by the simultaneous reduction in the expression of the statin target enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |