Title : Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type.

Pub. Date : 2021 Jun 8

PMID : 34136086






1 Functional Relationships(s)
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1 Sensitivity to nelfinavir was due to the IU-TAB-1 cell line"s gain-of function (GOF) mutation in PIK3CA and amplification of genes observed from array comparative genomic hybridization (aCGH), including AURKA, ERBB2, KIT, PDGFRA and PDGFB, that are known upregulate AKT, while resistance to everolimus was primarily driven by upregulation of downstream signaling of KIT, PDGFRA and PDGFB in the presence of mTORC1 inhibition. Nelfinavir aurora kinase A Homo sapiens