Pub. Date : 2021 Aug 30
PMID : 34129049
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 2 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 3 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 4 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 5 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 6 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 7 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 8 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 9 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 10 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 11 | We hypothesized that the loss of TIPARP catalytic activity would increase sensitivity to TCDD-induced toxicity in vivo. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 12 | Treatment of mouse embryonic fibroblasts or hepatocytes isolated from TiparpH532A mice confirmed the increased TCDD-induced expression of the AHR target genes Cyp1a1, Cyp1b1 and Tiparp. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 13 | Taken together, these data further support TIPARP as a critical negative regulator of AHR activity and show that loss of its catalytic activity is sufficient to increase sensitivity to TCDD-induced steatohepatitis and lethality. | Polychlorinated Dibenzodioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |