Title : Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.

Pub. Date : 2021 Aug 17

PMID : 34125594






2 Functional Relationships(s)
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1 Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1). remdesivir cathepsin A Homo sapiens
2 Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1). remdesivir cathepsin A Homo sapiens