Title : Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle.

Pub. Date : 2021 Jun 12

PMID : 34118944






2 Functional Relationships(s)
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1 METHODS: mTORC1 signaling and muscle protein synthesis (MPS) were determined in vivo in a randomized controlled trial of 14 subjects (10 M, 4 F; 26 +- 4 year) that ingested 10 g of essential amino acids (EAA) after receiving 750 mg of chloroquine (CHQ, n = 7) or serving as controls (CON, n = 7; no chloroquine). Amino Acids, Essential CREB regulated transcription coactivator 1 Mus musculus
2 RESULTS: mTORC1, S6K1, 4E-BP1 and rpS6 phosphorylation increased in both CON and CHQ 1 h post EAA ingestion (P < 0.05). Amino Acids, Essential CREB regulated transcription coactivator 1 Mus musculus