Title : Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.

Pub. Date : 2021 Jul 13

PMID : 34115964






1 Functional Relationships(s)
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1 By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase (AMPK) or NF-kappaB, metformin blocked LPS-induced and ATP-dependent mitochondrial (mt) DNA synthesis and generation of oxidized mtDNA, an NLRP3 ligand. Metformin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens