Title : Molecular insight into isoform specific inhibition of PI3K-α and PKC-η with dietary agents through an ensemble pharmacophore and docking studies.

Pub. Date : 2021 Jun 9

PMID : 34108504






1 Functional Relationships(s)
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1 However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy. oleandrin HRas proto-oncogene, GTPase Homo sapiens