Title : Reprogramming of the Ethanol Stress Response in Saccharomyces cerevisiae by the Transcription Factor Znf1 and Its Effect on the Biosynthesis of Glycerol and Ethanol.

Pub. Date : 2021 Jul 27

PMID : 34105981






7 Functional Relationships(s)
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1 Reprogramming of ethanol stress response in S. cerevisiae by the transcription factor Znf1 and the effect on the biosynthesis of glycerol and ethanol. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C
2 Reprogramming of ethanol stress response in S. cerevisiae by the transcription factor Znf1 and the effect on the biosynthesis of glycerol and ethanol. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C
3 Here, we report a new transcription factor of ethanol stress adaptation called Znf1. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C
4 Overexpression of ZNF1 not only confers tolerance to high ethanol but also increases ethanol production by 4.6% (8.43 g/L) or 2.8% (75.78 g/L) when using 2% or 20% (w/v) glucose as a substrate, respectively, compared to the wild-type strain. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C
5 Overexpression of ZNF1 not only confers tolerance to high ethanol but also increases ethanol production by 4.6% (8.43 g/L) or 2.8% (75.78 g/L) when using 2% or 20% (w/v) glucose as a substrate, respectively, compared to the wild-type strain. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C
6 Mutually, stress-responsive transcription factors Msn2/4, Hsf1, and Yap1 are associated with some promoters of Znf1"s target genes to promote ethanol stress tolerance. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C
7 Here, role of Znf1 in ethanol stress response is defined. Ethanol DNA-binding domain containing protein Saccharomyces cerevisiae S288C