Pub. Date : 2021 Jun 8
PMID : 34103339
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha inhibitors used as steroid-sparing maintenance monotherapy in parenchymal CNS sarcoidosis. | Steroids | tumor necrosis factor | Homo sapiens |
| 2 | OBJECTIVE: To assess the efficacy of tumour necrosis factor-alpha (TNF-alpha) inhibitors used as steroid-sparing monotherapy in central nervous system (CNS) parenchymal sarcoidosis. | Steroids | tumor necrosis factor | Homo sapiens |
| 3 | METHODS: The French Multiple Sclerosis and Neuroinflammation Centers retrospectively identified patients with definite or probable CNS sarcoidosis treated with TNF-alpha inhibitors as steroid-sparing monotherapy. | Steroids | tumor necrosis factor | Homo sapiens |
| 4 | The mean (SD) minimum dose of steroids was 31.5 (33) mg before TNF-alpha inhibitor initiation and 6.5 (5.5) mg after (p=0.001). | Steroids | tumor necrosis factor | Homo sapiens |
| 5 | CONCLUSION: TNF-alpha inhibitors can greatly reduce steroids dosing in patients with CNS parenchymal sarcoidosis, even refractory. | Steroids | tumor necrosis factor | Homo sapiens |