Pub. Date : 2021 Dec
PMID : 34101105
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib. | Lapatinib | erb-b2 receptor tyrosine kinase 3 | Homo sapiens |
| 2 | HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib. | Lapatinib | erb-b2 receptor tyrosine kinase 3 | Homo sapiens |
| 3 | PROCEDURES: In a panel of HER2+ breast cancer cell lines treated with the HER2 inhibitor lapatinib, we evaluate changes in HER3 expression and viability. | Lapatinib | erb-b2 receptor tyrosine kinase 3 | Homo sapiens |
| 4 | RESULTS: Lapatinib treatment of a panel of HER2+ breast cancer cell lines increased HER3 expression in the lapatinib-resistant cell line MDA-MB 453 but not the lapatinib-resistant cell-line HCC-1569. | Lapatinib | erb-b2 receptor tyrosine kinase 3 | Homo sapiens |
| 5 | RESULTS: Lapatinib treatment of a panel of HER2+ breast cancer cell lines increased HER3 expression in the lapatinib-resistant cell line MDA-MB 453 but not the lapatinib-resistant cell-line HCC-1569. | Lapatinib | erb-b2 receptor tyrosine kinase 3 | Homo sapiens |
| 6 | The additional knockdown of HER3 increased therapeutic efficacy of lapatinib only in MDA-MB453 cells, but not in HCC-1569 cells. | Lapatinib | erb-b2 receptor tyrosine kinase 3 | Homo sapiens |