Pub. Date : 2021 Jul
PMID : 34095989
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IDH mutations induce a neomorphic enzyme that converts alpha-ketoglutarate to the oncometabolite D-2-hydroxyglutarate, which leads to widespread effects on cellular epigenetics and metabolism. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Targeting D-2-hydroxyglutarate is considered a novel attractive therapeutic approach for low-grade gliomas and the insights from clinical trials suggest that mutant-selective IDH inhibitors are the ideal candidates, with a favorable benefit/risk ratio. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |