Title : SMYD3-PARP16 axis accelerates unfolded protein response and mediates neointima formation.

Pub. Date : 2021 May

PMID : 34094832






1 Functional Relationships(s)
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1 Using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) analysis, PARP16 was identified as a novel target gene for histone H3 lysine 4 (H3K4) methyltransferase SMYD3, and SMYD3 could bind to the promoter of Parp16 and increased H3K4me3 level to activate its host gene"s transcription, which causes UPR activation and SMC proliferation. Lysine SET and MYND domain containing 3 Homo sapiens