Pub. Date : 2021 Jun 4
PMID : 34094715
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence. | trmp-s | dynactin subunit 6 | Homo sapiens |
| 2 | Here we characterize a second major splice variant, TRMP-S (short variant), whose enforced loss promotes cancer cell-cycle arrest and p27-dependent entry into cellular senescence. | trmp-s | dynactin subunit 6 | Homo sapiens |
| 3 | Remarkably, despite sharing a single common exon with TRMP, TRMP-S restrains p27 expression through distinct mechanisms. | trmp-s | dynactin subunit 6 | Homo sapiens |
| 4 | First, TRMP-S stabilizes UHRF1 protein levels, an epigenetic inhibitor of p27, by promoting interactions between UHRF1 and its deubiquitinating enzyme USP7. | trmp-s | dynactin subunit 6 | Homo sapiens |
| 5 | Alternatively, binding interactions between TRMP-S and FUBP3 prevent p53 mRNA interactions with RPL26 ribosomal protein, the latter essential for promoting p53 translation with ensuing suppression of p53 translation limiting p27 expression. | trmp-s | dynactin subunit 6 | Homo sapiens |