Pub. Date : 2021
PMID : 34093539
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Here, we firstly reported that remdesivir (RDV, GS-5734), a broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in macrophages. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Here, we firstly reported that remdesivir (RDV, GS-5734), a broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in macrophages. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Here, we firstly reported that remdesivir (RDV, GS-5734), a broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in macrophages. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Here, we firstly reported that remdesivir (RDV, GS-5734), a broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in macrophages. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Here, we firstly reported that remdesivir (RDV, GS-5734), a broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in macrophages. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | Here, we firstly reported that remdesivir (RDV, GS-5734), a broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in macrophages. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 8 | Mechanically, RDV effectively suppressed the activities of nuclear transcription factor (NF)-kappaB, mitogen-activated protein kinase (MAPK), which further led to the reduction of the inflammasome genes of NLRP3 transcription, limiting the activation of NLRP3 inflammasome in vivo and in vitro. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |
| 9 | Mechanically, RDV effectively suppressed the activities of nuclear transcription factor (NF)-kappaB, mitogen-activated protein kinase (MAPK), which further led to the reduction of the inflammasome genes of NLRP3 transcription, limiting the activation of NLRP3 inflammasome in vivo and in vitro. | remdesivir | NLR family pyrin domain containing 3 | Homo sapiens |