Title : The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on SIRT1-mediated regulation of PERK acetylation.

Pub. Date : 2021 Aug

PMID : 34089864






5 Functional Relationships(s)
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1 Furthermore, pre-incubation of VSMCs with terpinen-4-ol or a SIRT1 agonist, decreased beta-GP-induced calcium salt deposition, increased SIRT1 protein level, and inhibited PERK-eIF2alpha-ATF4 pathway activation, thus, alleviating VC. terpinenol-4 sirtuin 1 Mus musculus
2 Furthermore, pre-incubation of VSMCs with terpinen-4-ol or a SIRT1 agonist, decreased beta-GP-induced calcium salt deposition, increased SIRT1 protein level, and inhibited PERK-eIF2alpha-ATF4 pathway activation, thus, alleviating VC. terpinenol-4 sirtuin 1 Mus musculus
3 Finally, inhibition of SIRT1 reduced the effect of terpinen-4-ol on the deacetylation of PERK in vitro and in vivo and weakened the inhibitory effect of terpinen-4-ol against ER stress-mediated VC. terpinenol-4 sirtuin 1 Mus musculus
4 Finally, inhibition of SIRT1 reduced the effect of terpinen-4-ol on the deacetylation of PERK in vitro and in vivo and weakened the inhibitory effect of terpinen-4-ol against ER stress-mediated VC. terpinenol-4 sirtuin 1 Mus musculus
5 Cumulatively, terpinen-4-ol was found to inhibit post-translational modification of PERK at the K889 acetylation site by upregulating SIRT1 expression, thereby ameliorating VC by regulating ER stress. terpinenol-4 sirtuin 1 Mus musculus