Title : Combination of two miRNAs has a stronger effect on stimulating apoptosis, inhibiting cell growth, and increasing erlotinib sensitivity relative to single miRNA in A549 lung cancer cells.

Pub. Date : 2021 Jun 3

PMID : 34081797






3 Functional Relationships(s)
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1 Other experiments indicated that up-regulation of each of miRNA-125a-5p or miRNA-145 inhibited cell growth, induced apoptosis, and markedly decreased the IC50 value of erlotinib in A549 lung cancer cells(P<0.05). Erlotinib Hydrochloride microRNA 145 Homo sapiens
2 Both miRNA-125a-5p and miRNA-145 suppress the expression of EGFR gene Down-regulation of EGFR enhances the proliferation of the A549 lung cancer cells MiRNA-125a-5p and miRNA-145 reduce the erlotinib resistance in A549 cells Sensitization effects of miRNAs is linked to the enhancement of apoptosis This article is protected by copyright. Erlotinib Hydrochloride microRNA 145 Homo sapiens
3 Both miRNA-125a-5p and miRNA-145 suppress the expression of EGFR gene Down-regulation of EGFR enhances the proliferation of the A549 lung cancer cells MiRNA-125a-5p and miRNA-145 reduce the erlotinib resistance in A549 cells Sensitization effects of miRNAs is linked to the enhancement of apoptosis This article is protected by copyright. Erlotinib Hydrochloride microRNA 145 Homo sapiens