Pub. Date : 2021 Mar-Apr
PMID : 34076978
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long noncoding RNA NEAT1 aggravates sorafenib-resistance in non-small cell lung cancer via regulating miRNA-335/c-Met. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |
| 2 | PURPOSE: The purpose of this study was to illustrate the role of long non-coding RNA (lncRNA) NEAT1 in inhibiting sorafenib sensitivity in non-small cell lung cancer (NSCLC) through targeting microRNA-335 (miR-335)/c-Met axis. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |
| 3 | METHODS: Regulatory effects of NEAT1/miR-335/c-Met axis on proliferative ability of sorafenib-induced A549 and PC9 cells were assessed by cell counting kit-8 (CCK-8) and colony formation assay. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |
| 4 | Apoptosis changes influenced by nuclear paraspeckle assembly transcript 1 (NEAT1)/miR-335/c-Met axis after sorafenib treatment in lung cancer cells were examined by detecting apoptotic rate, as well as relative levels of Bcl-2 and Bax. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |
| 5 | RESULTS: Sorafenib treatment in A549 cells and PC9 cells attenuated the proliferation and induced apoptosis, which were more pronounced after silencing of NEAT1. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |
| 6 | Rescue experiments verified the role of NEAT1/ MiR-335/c-Met regulatory loop in reducing the proliferative ability and inducing apoptosis of sorafenib-treated lung cancer cells. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |
| 7 | CONCLUSIONS: LncRNA NEAT1 aggravates sorafenib resistance in NSCLC through inhibiting MiR-335 to upregulate c-Met level, manifesting as attenuated proliferation and accelerated apoptosis. | Sorafenib | nuclear paraspeckle assembly transcript 1 | Homo sapiens |