Title : Simultaneous detection of tumor-related mRNA and miRNA in cancer cells with magnetic SERS nanotags.

Pub. Date : 2021 Sep 1

PMID : 34074418






4 Functional Relationships(s)
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1 Herein, we reported a low cost and sensitive SERS sensing platform for simultaneous p21 mRNA and miRNA-21 detection based on duplex-specific nuclease signal amplification (DSNSA) plus multifunctional Fe3O4@SiO2 magnetic nanoparticles (Fe3O4@SiO2 MNPs). ferryl iron seryl-tRNA synthetase 1 Homo sapiens
2 Herein, we reported a low cost and sensitive SERS sensing platform for simultaneous p21 mRNA and miRNA-21 detection based on duplex-specific nuclease signal amplification (DSNSA) plus multifunctional Fe3O4@SiO2 magnetic nanoparticles (Fe3O4@SiO2 MNPs). ferryl iron seryl-tRNA synthetase 1 Homo sapiens
3 Here, Fe3O4@SiO2 MNPs were used as a separation substrate, and Au@AgNPs served as stable and ultrasensitive SERS nanotags. ferryl iron seryl-tRNA synthetase 1 Homo sapiens
4 Under the assistance of the target p21 mRNA and miRNA-21, DNA (CP) of the DNA-RNA heteroduplexes could be specifically degraded by DSN and the SERS nanotags that were released from the surface of Fe3O4@SiO2 MNPs. ferryl iron seryl-tRNA synthetase 1 Homo sapiens