Title : Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism.

Pub. Date : 2021 May 10

PMID : 34068624






1 Functional Relationships(s)
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1 We found that cells with SIRT2 inhibition revealed increased sensitivity to cisplatin and exhibited increased accumulation of gamma-H2AX and reduced EGFR-AKT-RAF-ERK1/2 (epidermal growth factor receptor-protein B kinase-RAF kinase-extracellular signal-regulated kinase 1/2) pathway signaling compared to control cells. Cisplatin AKT serine/threonine kinase 1 Homo sapiens