Pub. Date : 2021 May 22
PMID : 34067439
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ezetimibe is a well-known drug that lowers blood cholesterol levels by reducing its absorption in the small intestine when joining to Niemann-Pick C1-like protein (NPC1L1). | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | It also shows interesting results when it comes to a pharmacophore study based on ezetimibe as the main ligand in lowering blood cholesterol levels, revealing which substituents on the azetidine-2-one ring are more similar to the ezetimibe skeleton and will more likely bind to NPC1L1 than ezetimibe. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |