Pub. Date : 2021 May 16
PMID : 34065652
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proteomics studies have identified lysine acetylation in WT IDH1, indicating post-translational regulation. | Lysine | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Here, we generated lysine to glutamine acetylation mimic mutants in IDH1 to evaluate the effects on activity. | Lysine | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | We show that mimicking lysine acetylation decreased the catalytic efficiency of WT IDH1, with less severe catalytic consequences for R132H IDH1. | Lysine | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |