Pub. Date : 2021 Jun 25
PMID : 34060590
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The oxidatively generated genotoxic spiroiminodihydantoin (Sp) lesions are well-known substrates of base excision repair (BER) pathway initiated by the bifunctional DNA glycosylase NEIL1. | spiroiminodihydantoin | nei like DNA glycosylase 1 | Homo sapiens |
| 2 | The oxidatively generated genotoxic spiroiminodihydantoin (Sp) lesions are well-known substrates of base excision repair (BER) pathway initiated by the bifunctional DNA glycosylase NEIL1. | spiroiminodihydantoin | nei like DNA glycosylase 1 | Homo sapiens |
| 3 | In this work we reported that the excision kinetics of the single Sp lesions site-specifically embedded in the covalently closed circular DNA plasmids (contour length 2686 base pairs) by NEIL1 are biphasic under single-turnover conditions ((NEIL1)>>(SpDNApl)) in contrast to monophasic excision kinetics of the same lesions embedded in147-mer Sp-modified DNA duplexes. | spiroiminodihydantoin | nei like DNA glycosylase 1 | Homo sapiens |
| 4 | In this work we reported that the excision kinetics of the single Sp lesions site-specifically embedded in the covalently closed circular DNA plasmids (contour length 2686 base pairs) by NEIL1 are biphasic under single-turnover conditions ((NEIL1)>>(SpDNApl)) in contrast to monophasic excision kinetics of the same lesions embedded in147-mer Sp-modified DNA duplexes. | spiroiminodihydantoin | nei like DNA glycosylase 1 | Homo sapiens |