Title : Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions.

Pub. Date : 2021 Aug

PMID : 34058788






1 Functional Relationships(s)
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1 However, binding of a human soluble SIRPalpha -Fc fusion protein to SEN177 treated cancer cells was significantly reduced in a dose-dependent manner, suggesting that pyro-glutamate formation of CD47 was affected. Pyrrolidonecarboxylic Acid CD47 molecule Homo sapiens