Title : Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.

Pub. Date : 2021 Oct 6

PMID : 34058387






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1 Here, we show that reducing NKCC1 expression by RNA interference in the Ts65Dn mouse model of Down syndrome (DS) restores intracellular chloride concentration, efficacy of GABA-mediated inhibition and neuronal network dynamics in vitro and ex vivo. gamma-Aminobutyric Acid solute carrier family 12, member 2 Mus musculus