Title : The glutathionylation agent disulfiram augments superoxide/hydrogen peroxide production when liver mitochondria are oxidizing ubiquinone pool-linked and branched chain amino acid substrates.

Pub. Date : 2021 Aug 20

PMID : 34052343






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Our group has previously observed that protein S-glutathionylation serves as an integral feedback inhibitor for the production of superoxide (O2 -)/hydrogen peroxide (H2O2) by alpha-ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and complex I in muscle and liver mitochondria, respectively. Hydrogen Peroxide pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens
2 Our group has previously observed that protein S-glutathionylation serves as an integral feedback inhibitor for the production of superoxide (O2 -)/hydrogen peroxide (H2O2) by alpha-ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and complex I in muscle and liver mitochondria, respectively. Hydrogen Peroxide pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens
3 Our group has previously observed that protein S-glutathionylation serves as an integral feedback inhibitor for the production of superoxide (O2 -)/hydrogen peroxide (H2O2) by alpha-ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and complex I in muscle and liver mitochondria, respectively. Hydrogen Peroxide pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens
4 Our group has previously observed that protein S-glutathionylation serves as an integral feedback inhibitor for the production of superoxide (O2 -)/hydrogen peroxide (H2O2) by alpha-ketoglutarate dehydrogenase (KGDH), pyruvate dehydrogenase (PDH), and complex I in muscle and liver mitochondria, respectively. Hydrogen Peroxide pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens