Title : Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit.

Pub. Date : 2021 Jul

PMID : 34048091






1 Functional Relationships(s)
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1 Pre-incubation of retina with L-methionine-sulfoximine (an inhibitor of glutamine synthetase) also abolished NMDAR-mediated noise in AII, but not A17 amacrines, suggesting a neuronal source of glutamate activates AII NMDARs, whereas a glial source activates A17 NMDARs. L-Methionine sulfoximine immunoglobulin kappa variable 2-30 Homo sapiens