Title : Selective killing of transformed cells by mechanical stretch.

Pub. Date : 2021 Aug

PMID : 34044258






1 Functional Relationships(s)
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1 The mechanism of mechanical apoptosis (mechanoptosis) of transformed cells involves calcium influx through the mechanosensitive channel, Piezo1 that activates calpain 2 dependent apoptosis through the BAX molecule and subsequent mitochondrial activation of caspase 3 on both fibronetin and collagen matrices. Calcium caspase 3 Homo sapiens