Title : Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.

Pub. Date : 2021 Jun 10

PMID : 34038119






1 Functional Relationships(s)
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1 Our first disclosed clinical ROMK compound, 2 (MK-7145), demonstrated robust diuresis, natriuresis, and blood pressure lowering in preclinical models, with reduced urinary potassium excretion compared to the standard of care diuretics. MK-7145 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens