Title : Septin 4 activates PPARγ/LXRα signaling by upregulating ABCA1 and ABCG1 expression to inhibit the formation of THP-1 macrophage-derived foam cells.

Pub. Date : 2021 Jul

PMID : 34035860






1 Functional Relationships(s)
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1 Additionally, blocking PPARgamma activity using its inhibitor T0070907 or knocking down LXRalpha expression using short hairpin RNA reversed the effects of Septin 4 overexpression on foam cell formation and cholesterol handling. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens