Pub. Date : 2022 Feb
PMID : 34032273
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of aminoglycosides based on MT-RNR1 genotype. | Aminoglycosides | mitochondrially encoded 12S RNA | Homo sapiens |
| 2 | Some MT-RNR1 variants (i.e., m.1095T>C; m.1494C>T; m.1555A>G) more closely resemble the bacterial 16s rRNA subunit and result in increased risk of aminoglycoside-induced hearing loss. | Aminoglycosides | mitochondrially encoded 12S RNA | Homo sapiens |
| 3 | Use of aminoglycosides should be avoided in individuals with an MT-RNR1 variant associated with an increased risk of aminoglycoside-induced hearing loss unless the high risk of permanent hearing loss is outweighed by the severity of infection and safe or effective alternative therapies are not available. | Aminoglycosides | mitochondrially encoded 12S RNA | Homo sapiens |
| 4 | Use of aminoglycosides should be avoided in individuals with an MT-RNR1 variant associated with an increased risk of aminoglycoside-induced hearing loss unless the high risk of permanent hearing loss is outweighed by the severity of infection and safe or effective alternative therapies are not available. | Aminoglycosides | mitochondrially encoded 12S RNA | Homo sapiens |
| 5 | We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of aminoglycosides based on MT-RNR1 genotype (updates at https://cpicpgx.org/guidelines/ and www.pharmgkb.org). | Aminoglycosides | mitochondrially encoded 12S RNA | Homo sapiens |