Pub. Date : 2021 Jun 4
PMID : 34026326
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-204 silencing reduces mitochondrial autophagy and ROS production in a murine AD model via the TRPML1-activated STAT3 pathway. | Reactive Oxygen Species | mucolipin 1 | Mus musculus |
| 2 | TRPML1 overexpression, downregulation of miR-204, or STAT3 pathway activation reduced the Abeta1-42-induced mitochondrial damage, along with ROS production and mitochondrial autophagy in vivo and in vitro. | Reactive Oxygen Species | mucolipin 1 | Mus musculus |
| 3 | Silencing of miR-204 could upregulate TRPML1 expression, thus suppressing ROS production and mitochondrial autophagy in AD through STAT3 pathway. | Reactive Oxygen Species | mucolipin 1 | Mus musculus |