Title : miR-204 silencing reduces mitochondrial autophagy and ROS production in a murine AD model via the TRPML1-activated STAT3 pathway.

Pub. Date : 2021 Jun 4

PMID : 34026326






2 Functional Relationships(s)
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1 TRPML1 overexpression, downregulation of miR-204, or STAT3 pathway activation reduced the Abeta1-42-induced mitochondrial damage, along with ROS production and mitochondrial autophagy in vivo and in vitro. Reactive Oxygen Species signal transducer and activator of transcription 3 Mus musculus
2 Silencing of miR-204 could upregulate TRPML1 expression, thus suppressing ROS production and mitochondrial autophagy in AD through STAT3 pathway. Reactive Oxygen Species signal transducer and activator of transcription 3 Mus musculus