Title : IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Pub. Date : 2021

PMID : 34025677






1 Functional Relationships(s)
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1 Here we show that tumoral IDO1 expression led to profound changes in tryptophan, nicotinate/nicotinamide, and purine metabolic pathways in the ovarian tumor microenvironment, and to an increased frequency of PD-1+CD8+ tumor infiltrating T cells. Niacin indoleamine 2,3-dioxygenase 1 Sus scrofa