Pub. Date : 2021 Jul 1
PMID : 34019311
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report that loss of function of lysosomal Niemann-Pick Type C1 (NPC1) cholesterol transporter, which leads to neurodegenerative NPC disease, initiates a signaling cascade that alters the cholesterol/phosphatidylinositol 4-phosphate (PtdIns4P) countertransport cycle between Golgi-endoplasmic reticulum (ER), as well as lysosome-ER membrane contact sites (MCS). | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | We report that loss of function of lysosomal Niemann-Pick Type C1 (NPC1) cholesterol transporter, which leads to neurodegenerative NPC disease, initiates a signaling cascade that alters the cholesterol/phosphatidylinositol 4-phosphate (PtdIns4P) countertransport cycle between Golgi-endoplasmic reticulum (ER), as well as lysosome-ER membrane contact sites (MCS). | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |