Pub. Date : 2021 Jul
PMID : 34018041
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The density of medium CR + interneurons is significantly decreased in the dopamine-depleted striatum (158 +- 15 neurons/mm3), when compared to sham animals (370 +- 41 neurons/mm3), whereas that of the small-sized CR + interneurons is unchanged (174 +- 46 neurons/mm3 in 6-OHDA-lesioned striatum and 164 +- 22 neurons/mm3 in sham-lesioned striatum). | Dopamine | calbindin 2 | Mus musculus |
| 2 | The density of medium CR + interneurons is significantly decreased in the dopamine-depleted striatum (158 +- 15 neurons/mm3), when compared to sham animals (370 +- 41 neurons/mm3), whereas that of the small-sized CR + interneurons is unchanged (174 +- 46 neurons/mm3 in 6-OHDA-lesioned striatum and 164 +- 22 neurons/mm3 in sham-lesioned striatum). | Dopamine | calbindin 2 | Mus musculus |
| 3 | Our results provide the first evidence that the medium-sized striatal interneurons expressing low level of CR are specifically targeted by dopamine denervation, while the small and intensely immunoreactive CR + cells remain unaffected. | Dopamine | calbindin 2 | Mus musculus |