Title : Curcumin alleviates inflammation in Takayasu's arteritis by blocking CCL2 overexpression in adventitial fibroblasts.

Pub. Date : 2021 Mar-Apr

PMID : 34014157






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway. Curcumin AKT serine/threonine kinase 1 Homo sapiens
2 The inhibitory effect of curcumin on the JAK2/AKT/STAT3 pathway was even more obvious than that of methotrexate and tofacitinib. Curcumin AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway. Curcumin AKT serine/threonine kinase 1 Homo sapiens