Title : Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine.

Pub. Date : 2021 May 19

PMID : 34011935






2 Functional Relationships(s)
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1 We found that downregulation of the MMP1 protein was a key abnormal feature in the neurofibromatosis 1 fibroblasts and that the decreased MMP1 was restored by the lysosomal blockers CQ and HCQ, but not by the blockers of the Ras pathway. Hydroxychloroquine matrix metallopeptidase 1 Homo sapiens
2 We found that downregulation of the MMP1 protein was a key abnormal feature in the neurofibromatosis 1 fibroblasts and that the decreased MMP1 was restored by the lysosomal blockers CQ and HCQ, but not by the blockers of the Ras pathway. Hydroxychloroquine matrix metallopeptidase 1 Homo sapiens