Pub. Date : 2021 May 19
PMID : 34011327
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | SAL also attenuated LPS-induced activation of NLRP3 inflammasome, reduced the protein expression of NLRP3-related proteins, including ASC and caspase-1. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | SAL also attenuated LPS-induced activation of NLRP3 inflammasome, reduced the protein expression of NLRP3-related proteins, including ASC and caspase-1. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Autophagy inhibition by 3-MA markedly reversed SAL-modulated changes in cell viability and NLRP3 expression in LPS-stimulated HUVECs. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | CONCLUSION: SAL protects endothelial cells against LPS-induced injury through inhibition of NLRP3 pathways and enhancing autophagy. | rhodioloside | NLR family pyrin domain containing 3 | Homo sapiens |