Title : MicroRNAs modulation and clinical outcomes at 1 year of follow-up in obese patients with pre-diabetes treated with metformin vs. placebo.

Pub. Date : 2021 Oct

PMID : 34009437






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Obese pre-diabetics in metformin vs. placebo showed significant reduction in serum miR-195 and miR-27 (p < 0.05). Metformin microRNA 27a Homo sapiens
2 Obese pre-diabetics in metformin vs. normoglycemics showed higher expression of serum miR-195 and miR-27 (p < 0.05). Metformin microRNA 27a Homo sapiens
3 CONCLUSIONS: In obese pre-diabetics", metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT. Metformin microRNA 27a Homo sapiens