Pub. Date : 2021 Sep
PMID : 34002944
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma. | Hydroxychloroquine | SMAD family member 4 | Homo sapiens |
| 2 | We studied whether HCQ treatment in SMAD4 deficient PDA may prevent therapeutic resistance induced by autophagy upregulation. | Hydroxychloroquine | SMAD family member 4 | Homo sapiens |
| 3 | The effect of SMAD4 loss on response to HCQ and chemotherapy was studied for association with clinical outcome. | Hydroxychloroquine | SMAD family member 4 | Homo sapiens |
| 4 | 76% of HCQ-treated patients with SMAD4 loss obtained a histopathologic response greater than or equal to 2A, compared with only 37% with SMAD4 intact (p = 0.006). | Hydroxychloroquine | SMAD family member 4 | Homo sapiens |
| 5 | The addition of HCQ to neoadjuvant chemotherapy in patients with PDA may improve treatment response in those with SMAD4 loss. | Hydroxychloroquine | SMAD family member 4 | Homo sapiens |