Title : Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.

Pub. Date : 2021 Jan-Jun

PMID : 34000301






1 Functional Relationships(s)
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1 Moreover, depletion of the pyrimidine synthesis enzymes carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) and dihydroorotate dehydrogenase (DHODH) activated autophagy as well, although mTORC1 activity was not altered by pyrimidine shortage. pyrimidine CREB regulated transcription coactivator 1 Mus musculus