Pub. Date : 2021 Sep
PMID : 33991530
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 2 | The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 3 | The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 4 | The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 5 | The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 6 | However, it remains unknown whether endogenous hepcidin regulates ferroportin-mediated iron reabsorption under physiological conditions, and whether such regulation is important for kidney and/or systemic iron homeostasis. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 7 | Thus, our study demonstrates that endogenous hepcidin controls ferroportin-mediated tubular iron reabsorption under physiological conditions. | Iron | hepcidin antimicrobial peptide | Mus musculus |