Pub. Date : 2021 May 14
PMID : 33990641
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | However, here we found that in the case of CDDP-induced apoptosis, EA-mediated pro-apoptotic action was reversed by knockout of either p53 or ASK1, despite no increase in p53 apoptotic activity. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | These results demonstrate that in response to CDDP ICLs, TFAs promote p53-dependent apoptosis through the enhancement of the Nox-RIP1-ASK1-MAPK pathway activation, providing insight into the diverse pathogenetic mechanisms of TFAs according to the types of DNA damage. | Cisplatin | tumor protein p53 | Homo sapiens |