Title : Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.

Pub. Date : 2021 Jul

PMID : 33984439






1 Functional Relationships(s)
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1 Moreover, cynaroside restored pyruvate kinase activity, inhibited glycolysis-related proteins including PFKFB3, HK2 and HIF-1alpha, and inhibited glycolysis-related hyperacetylation of HMGB1 in septic liver. luteolin-7-glucoside hexokinase 2 Mus musculus